-
Jacobs, okay. B. et al. apparent clonal mosaicism and its relationship to aging and melanoma. Nat. Genet. , –.
CAS PubMed PubMed significant Google scholar
-
Laurie, C. C. et al. detectable clonal mosaicism from beginning to ancient age and its relationship to melanoma. Nat. Genet. forty-four, –.
CAS PubMed PubMed relevant Google student
-
Genovese, G. et al. Clonal hematopoiesis and blood-melanoma chance accepted from claret DNA sequence. N. Engl. J. Med. , –.
-
Jaiswal, S. et al. Age-related clonal hematopoiesis associated with adversarial effects. N. Engl. J. Med. , –.
Monogenic & polygenic inheritance develop into instruments for clonal alternative
![Monogenic polygenic inheritance develop into instruments](https://www.medlinepluss.uk/wp-content/uploads/2020/08/Monogenic-polygenic-inheritance-develop-into-instruments-300x236.jpg)
Machiela, M. J. et al. Characterization of enormous structural genetic mosaicism in human autosomes. Am. J. Hum. Genet. , –.
CAS PubMed PubMed critical Google pupil
-
Vattathil, S. & Scheet, P. extensive hidden genomic mosaicism published in average tissue. Am. J. Hum. Genet. ninety-eight, –.
CAS PubMed PubMed central Google pupil
Abelson, S. et al. anticipation of astute myeloid leukemia possibility in fit individuals. attributes, four hundred–.
CAS PubMed PubMed crucial ads Google scholar
-
Loh, P.-R. et al. Insights into clonal hematopoiesis from, mosaic chromosomal differences. attributes, –.
CAS PubMed PubMed vital adverts Google pupil
-
Bycroft, C. et al. the united kingdom Biobank useful resource with deep phenotyping and genomic data. nature, –.
CAS PubMed PubMed significant ads Google student
-
Uziel, T. et al. claim of the MRN complicated for ATM activation through DNA harm. EMBO J., –.
CAS PubMed PubMed valuable Google student
-
Lee, J.-H. & Paull, T. T. ATM activation through DNA double-strand breaks through the Mre-Rad-Nbs complicated. , –.
-
Deng, Y., Guo, X., Ferguson, D. O. & Chang, S. dissimilar roles for MRE at uncapped telomeres. attributes, –.
CAS PubMed PubMed central adverts Google student
Which of the following conditions occur through a monogenic?
-
Kimura, S., Roberts, A. W., Metcalf, D. & Alexander, W. S. Hematopoietic axis cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin. Proc. Natl Acad. Sci. u. s. , –.
-
photovoltaic, G. P. et al. position of c-mp in early hematopoiesis. claret, four–.
-
See, J. et al. Link abnormally regulate the cocky-renewal of hematopoietic axis cells by modifying thrombopoietin-advised sign transduction. Proc. Natl Acad. Sci. The USA, –.
-
Loh, P.-R., Palamara, P. F. & cost, A. L. quick and accurate long-latitude phasing in a UK Biobank cohort. Nat. Genet. forty-eight, –.
CAS PubMed PubMed important Google pupil
-
Loh, P.-R. et al. reference-based phasing the usage of the Haplotype reference consortium panel. Nat. Genet. forty-eight, –.
CAS PubMed PubMed valuable Google student
-
Auer, P. L. et al. rare and low-frequency coding variations in CXCR and different genes are linked to hematological features. Nat. Genet. forty-six, –.
CAS PubMed PubMed central Google student
-
Schultz, k. A. P. et al. PTEN, DICER, FH, and their associated tumor susceptibility syndromes: scientific po ints, genetics, and surveillance ideas in adolescence. Clin. melanoma Res. , e–e.
-
Landrum, M. J. et al. ClinVar: improving entry to alternative interpretations and supporting proof. Nucleic Acids Res. forty-six, D–D.
-
Van Hout, C. V. et al. total exome sequencing and assuming of coding model in, individuals in the UK Biobank. preprint at
-
Meuwissen, T. H., Hayes, B. J. & Goddard, M. E. prediction of complete genetic cost using genome-broad close brand maps. genetics, –.
CAS PubMed PubMed primary Google scholar
-
Purcell, S. M. et al. regular polygenic variation contributes to the chance of schizophrenia and bipolar sickness. attributes, –.
-
Khera, A. V. et al. Genome-wide polygenic scores for usual diseases determine people with chance corresponding to monogenic mutations. Nat. Genet. , –.
CAS PubMed PubMed principal Google scholar
monogenic diabetes symptoms
![monogenic diabetes symptoms](https://www.medlinepluss.uk/wp-content/uploads/2020/08/monogenic-diabetes-symptoms1-300x165.jpg)
-
Loh, P.-R. et al. effective Bayesian blended-model evaluation increases association vigor in huge cohorts. Nat. Genet. forty-seven, –.
CAS PubMed PubMed principal Google student
-
Thompson, D. J. et al. abiogenetic predisposition to circuitous Y chromosome loss in claret. nature, –.
CAS PubMed PubMed imperative Google student
-
Jaiswal, S. et al. Clonal hematopoiesis and the possibility of atherosclerotic cardiovascular disease. N. Engl. J. Med. , –.
-
Davoli, T. et al. cumulative haploinsufficiency and triple sensitivity pressure aneuploidy patterns and form the melanoma genome. one hundred fifty-five, –.
CAS PubMed PubMed valuable Google student
-
O’Keefe, C., McDevitt, M. A. & Maciejewski, J. P. blood a hundred and fifteen, –.
-
hunt, A. et al. profound affectionate bent linked to chromosome got uniparental disomy shows targeting of an imprinted locus. Leukemia, –.
CAS PubMed PubMed relevant Google student
-
choate, ok. A. et al. Mitotic recombination in patients with ichthyosis motives reversion of dominant mutations in KRT. , –ninety-seven.
CAS PubMed PubMed critical ads Google scholar
-
Tesi, B. et al. claret, –.
CAS PubMed PubMed imperative Google pupil
-
Schizophrenia alive group of the Psychiatric Genomics bunch. organic insights from schizophrenia-associated abiogenetic loci. attributes, –.
PubMed important advertisements Google pupil and monogenic
-
Sudlow, C. et al. UK biobank: inaugurate access to aid for selecting the factors of a big range of complicated diseases of core and historical age. PLoS Med. , e.
-
Wain, L. V. et al. Novel insights into the analysis of smoker behavior, lung characteristic, and persistent adverse pulmonary ailment UK BiLEVE: a genetic affiliation look at in UK Biobank. Lancet Respir. Med. three, –.
-
Das, S. et al. next-technology genotype imputation provider and methods. Nat. Genet. , –.
CAS PubMed PubMed critical Google scholar monogenic
-
Chang, C. C. et al. d-generation PLINK: rising to the challenge of higher and richer datasets. Gigascience four,
-
Diskin, S. J. et al. acclimation of genomic after-effects in sign intensities from entire-genome SNP genotyping systems. Nucleic Acids Res. , e.
-
Manichaikul, A. et al. powerful relationship inference in genome-broad association experiences. Bioinformatics, –.
CAS PubMed PubMed vital Google student
-
Rentzsch, P., Witten, D., Cooper, G. M., Shendure, J. & Kircher, M. CADD: admiration the deleteriousness of editions all the way through the animal genome. Nucleic Acids Res. forty-seven, D–D.
-
McLaren, W. et al. The Ensembl alternative effect predictor. Genome Biol. ,.
-
Thorvaldsdóttir, H., Robinson, J. T. & Mesirov, J. P. commutual Genomics eyewitness IGV: excessive-efficiency genomics records decision and analysis. quick. Bioinform. , –.
-
Pedersen, B. S. & Quinlan, A. R. Most depth: quick coverage adding for genomes and exomes. Bioinformatics, –.
Regier,
A. A. et al. purposeful adequation of genome sequencing analysis pipelines makes it possible for harmonized variant calling across human analysis initiatives.
monogenic vs polygenic Nat. Commun. ,.
PubMed principal adverts Google pupil monogenic vs polygenic
![PubMed principal adverts Google pupil monogenic vs polygenic](https://www.medlinepluss.uk/wp-content/uploads/2020/08/PubMed-principal-adverts-Google-pupil-monogenic-vs-polygenic-300x300.jpg)
-
Loh, P.-R., Michael, G., Gazal, S., Schoech, A. P. & cost, A. L. mixed-mannequin association for biobank-calibration datasets. Nat. Genet. , –.
CAS PubMed PubMed principal Google scholar
-
Arber, D. A. et al. The after light to the realm fitness organization classification of myeloid neoplasms and astute leukemia. blood, –.
CAS PubMed PubMed primary Google student
-
Jones, A. V. et al. JAK haplotype is a big possibility aspect of the construction of myeloproliferative neoplasms. Nat. Genet. , –.
CAS PubMed PubMed critical Google pupil
-
Kilpivaara, O. et al. A germline JAK SNP is associated with predisposition to the construction of JAK VF-high-quality myeloproliferative neoplasms. Nat. Genet. , –.
CAS PubMed PubMed important Google pupil
-
Olcaydu, D. et al. Nat. Genet. , – .
-
Koren, A. et al. abiogenetic version in animal DNA archetype timing. cell, –.
CAS PubMed PubMed primary Google pupil
-
Gusev, A. et al. complete inhabitants, genome-vast mapping of hidden relatedness. Genome Res. , –.
CAS PubMed PubMed relevant Google student